Brownian motion is too rough for ordinary calculus to work. Itô's Lemma is the chain rule for stochastic processes. For satisfying and a smooth function :
The extra term is what makes stochastic calculus different from ordinary calculus. It comes from the fact that — Brownian increments aren't negligible at second order.
Itô's Lemma is the workhorse of derivative pricing. Apply it to where follows GBM, and you get the SDE for log-returns. Apply it to an option payoff and you get the Black-Scholes PDE. Without Itô, modern continuous-time finance doesn't function.