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Steriles Business Change Lead
Closing Date: 6th July 2026 (COB)
Business Introduction
We manufacture and supply reliable, high-quality medicines and vaccines to meet patients’ needs and drive our performance.
Our network of 37 medicines and vaccines manufacturing sites delivered 1.7 billion packs of medicines and 409 million vaccine doses in 2024 to help make a positive impact on the health of millions of people. Our supply chain is not just core to our operations; it’s vital to bringing our innovations to patients as quickly, efficiently and effectively as possible. Technology is transforming how we manufacture medicines and vaccines, enabling us to increase the speed, quality and scale of product supply.
We need the very best minds and capability to help us on our journey to make more complex products, harnessing the power of smart manufacturing technologies including robotics, digital solutions and artificial intelligence to deliver for patients.
Position Summary
You will lead and shape business change for sterile manufacturing at a UK site. You will work across operations, engineering, quality and supply chain to design, plan and deliver change that improves safety, compliance and supply reliability. We value practical leadership, clear communication and a focus on developing people. This role offers visible career growth, meaningful impact and the chance to help GSK unite science, technology and talent to get ahead of disease together.
Responsibilities
This role will provide YOU the opportunity to lead key activities to progress YOUR career. These responsibilities include some of the following:
Design, develop and implement the site operational readiness roadmap for the SLT, including milestones, readiness criteria, acceptance thresholds and functional alignment across QA, Operations, Engineering, IT, Supply Chain, Finance, HR and EHS.
Act as the cross-functional integrator, coordinating readiness across commissioning, operations, compliance, people, processes, systems, safety, permits, commercial arrangements and organisational change.
Own the formal change control and governance process, including impact assessments, approvals, governance board updates, go/no-go decisions, rollback planning and the site change management plan.
Support commissioning, validation and sterile filling readiness, including IQ/OQ/PQ activities, water runs, media fills, PPQs, utilities, environmental monitoring and equipment readiness.
Ensure documentation and compliance readiness by updating controlled document registers, SOPs, work instructions, validation master plans, asset registers, emergency plans and regulatory submissions in line with internal and external standards.
Manage systems and data enablement, including CMMS/EAM, PLC/SCADA integration, MES, ERP, cybersecurity, access controls, data migration, asset hierarchies and system baselines.
Confirm safe operations, campaign readiness and regulatory compliance, including cleaning/sterilisation procedures, gowning validation, alarm functionality, product mix planning, campaign schedules, changeovers, shift patterns, permits, licences, HAZOP/HAZID and safety submissions.
Oversee post-go-live stabilisation with the SLT, monitoring reliability targets, process KPIs and operational performance, while supporting benefits realisation and ongoing enhancement after full operations go live.
Why You?
Basic Qualification
We are seeking professionals with the following required skills and qualifications to help us achieve our goals:
- Significant experience working in sterile pharmaceutical manufacturing or aseptic processing environments.
- Proven experience leading change, projects or operational transformations in a regulated site.
- Strong stakeholder management and clear communication with operations, engineering and quality teams.
- Experience defining requirements, supporting testing and delivering readiness for production.
- Demonstrable focus on GMP, compliance and inspection readiness.
- Ability and willingness to work on-site regularly and collaborate directly with shop floor teams.
Preferred Qualification
If you have the following characteristics, it would be a plus:
- Degree or vocational qualification in engineering, life sciences, manufacturing or a technical discipline.
- Experience with new product introductions, scale-up, transfers or capital project delivery.
- Familiarity with continuous improvement methods such as Lean or Six Sigma.
- Knowledge of manufacturing execution systems or electronic batch records.
- Experience coaching frontline leaders and building operational capability.
- Track record of delivering benefits through structured change and measurement.
Working model
This role is on-site at Barnard Castle. You should be prepared to spend significant time at the manufacturing site to lead activities and work directly with operational teams.
What we value in you
You are practical and calm under pressure. You set clear expectations and support others to meet them. You act with integrity and put safety and quality first. You make decisions using evidence and welcome learning. You create an inclusive workplace where different perspectives are heard and respected.
Apply now
If this role fits your skills and ambitions, we would like to hear from you. Please apply and tell us how your experience and values match this opportunity. We welcome applicants from varied backgrounds and encourage people who support an inclusive workplace to apply.
Why GSK?
Uniting science, technology and talent to get ahead of disease together.
GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases – to impact health at scale.
People and patients around the world count on the medicines and vaccines we make, so we’re committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.
GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.
We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.
Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us at UKRecruitment.Adjustments@gsk.com where you can also request a call.
Please note should your enquiry not relate to adjustments, we will not be able to support you through these channels. However, we have created a Recruitment FAQ guide. Click the link where you will find answers to multiple questions we receive
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