Senior Scientist, Safety Assessment

Position Overview

We are seeking an enthusiastic, self-motivated Senior Scientist to join the Nonclinical Development group, supporting the nonclinical safety assessment function for IND-enabling programs across Prime Medicine’s pipeline. Reporting to the Associate Director, Safety Assessment, the successful candidate will support the design, execution, and interpretation of nonclinical safety studies conducted both in-house and at CROs, with an initial focus on liver-targeted therapeutics. This role requires hands-on involvement in assay execution and troubleshooting, as well as active participation in study oversight of work being done at CRO and data analysis.

This role requires collaboration within cross-functional teams. The ideal candidate will hold a Ph.D. in toxicology or a related field with 6+ years of pharma/biotech experience in nonclinical safety assessment, or an M.S. in toxicology or a related field with 10+ years of experience in nonclinical safety assessment, the ability to work independently, provide domain expertise and leadership, as well as cross-functionally in a fast-paced, matrixed environment with a positive, flexible attitude.   

Primary Responsibilities

• Contribute to nonclinical safety activities as part of cross-functional Discovery and Development project teams, supporting program progression through IND-enabling stages.
• Design, execute, and troubleshoot nonclinical safety studies, including hands-on laboratory work (~30%) to support assay development, data generation, and issue resolution.
• Support the execution and oversight of nonclinical safety studies (GLP and non-GLP) at CROs, including active involvement in troubleshooting assay and study-related challenges.
• Analyze and interpret study data with guidance and contribute to the preparation of study reports and supporting documents for regulatory submissions.
• Collaborate with Pharmacology, DMPK, and other functions to support exploratory studies (e.g., exploratory toxicology, DMPK, biodistribution, and delivery platform evaluation).
• Contribute to evaluation of new delivery approaches, Lipid and RNA components, and emerging targets to support pipeline expansion.
• Assist in identifying potential safety findings and contribute to discussions on data interpretation and next steps.
• Ensure studies and internal activities are conducted in compliance with regulatory guidelines and internal standards.

Preferred Qualifications

• Ph.D. in toxicology or a related discipline with 6+ years of biopharmaceutical industry experience, or M.S. in toxicology or a related field with 10+ years of relevant biopharmaceutical industry experience supporting drug development in nonclinical safety/toxicology.
• Experience in large molecule therapeutic development, along with a background in immunology, is desirable.
• Understanding of toxicology principles, nonclinical safety evaluation, and the drug development process, with some experience interpreting toxicology data and contributing to technical and scientific reports.
• Demonstrates strong scientific judgment and leadership with the ability to evaluate information, identify potential issues, and propose practical solutions with guidance as needed.
• Highly organized and detail-oriented with strong attention to accuracy and quality.
• Strong communication and collaboration skills, with the ability to work effectively across multidisciplinary teams and with external partners.
• Experience supporting nonclinical studies at CROs is preferred but not required.