Staff Engineer, Sr. Manager

ROLE SUMMARY

Pfizer's committed to the application of computational science in the areas of drug discovery and development. As part of this mission, we have recently embarked on a large-scale migration of our computational infrastructure to cloud.

This role leverages extensive experience in cloud engineering and DevOps and requires a hands-on approach to designing and delivering robust High Performance Computing (HPC) solutions supporting computational workloads across the organization.

We are seeking an experienced individual to drive architecture, infrastructure automation, migration and operational excellence. You will collaborate with HPC engineers and scientific computing specialists to develop scalable cloud native infrastructure that underpins modernization of the scientific computing platform.

ROLE RESPONSIBILITIES

Platform Architecture and Engineering

• In this role you will design, implement, operate, and own robust and dependable infrastructure for HPC and ML/AI workloads in a cloud environment (AWS/GCP).

• Lead containerization, deployment, and operation of user- and admin-facing HPC platforms (Slurm, Open On Demand, Prometheus/Grafana, batch and distributed computing platforms) across cloud environments.

• Translate stakeholder input into robust, high-performance, scalable, cost effective computing platforms.

• Partner with HPC specialists (engineers, administrators, and users) to capture institutional knowledge and manual processes in IaC workflows, transforming ad-hoc deployment practices into reproducible, version-controlled, automated procedures.

Automation and DevOps

• Develop and maintain infrastructure automation using IaC tools like Terraform and CloudFormation to ensure repeatable environment provisioning and scaling.

• Create reusable Terraform modules. Develop and enforce standards. Be a driver for implementing and maintaining all cloud infrastructure using IaC tools.

• Operationalize containerized solutions using Docker and Kubernetes.

• Own the full lifecycle of infrastructure management, from provisioning to operations, support, updating, and teardown of production computing platforms.

• Perform troubleshooting, system analysis, and benchmarking to resolve issues and maintain a high-performance environment.

Monitoring and Reliability

• Develop and maintain monitoring, logging, and alerting for the infrastructure (e.g., CloudWatch, Prometheus/Grafana).

• Design new dashboards, workflows, and utilities to improve observability, cost monitoring, workload efficiency, user, or administration experience.

• Document architecture, deployment processes, and operational procedures.

• Partner closely with team members to support delivery of scientific computing services including user support, Linux administration, operations, job scheduling, application management, and resource optimization.

BASIC QUALIFICATIONS

• B.S. in computer science, life science, data science or similar fields.

• 6+ years of experience in cloud infrastructure engineering with a proven track record of developing and supporting robust IaC deployments.

• Experience managing scientific computing workloads in an enterprise environment.

• Advanced experience with at least one of AWS and GCP, including knowledge of core compute and storage services relevant to HPC.

• Solid understanding of cloud networking, identity, and security controls.

PREFERRED QUALIFICATIONS

• Prior experience with HPC deployment utilities including AWS ParallelCluster, AWS Parallel Computing Services, and Google Cloud Cluster Toolkit.

• Proficiency with distributed computing environments, especially EKS/GKE/Kubernetes.

• Familiarity with HPC environments, job schedulers (Slurm), HPC application containers (Docker, Singularity, Apptainer) and NVIDIA GPU computing.

Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.

NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS

Occasional international travel for team meetings and conferences.

OTHER JOB DETAILS:

• Last Date to Apply for Job: April 14th, 2026

• Work Location Assignment: Hybrid. Must be able to work from assigned Pfizer office 2-3 days per week, or as needed by the business


The annual base salary for this position ranges from $124,400.00 to $207,400.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 17.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.



This role is posted in multiple locations. If you are applying for the role in an secondary job posting location where pay transparency regulations apply, your Talent Advisor will share the local pay information with you during the first interview.




Relocation assistance may be available based on business needs and/or eligibility.




Candidates must be authorized to be employed in the U.S. by any employer.

U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future.






To learn more about acceptable and prohibited uses of AI during the recruitment process, please review our candidate AI-use guidelines available on Pfizer Careers.


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