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Director, Portfolio Strategy Inflammation & Immunology
PfizerUnited States - Massachusetts - Cambridge; United States - New York - New York City; United States - Pennsylvania - Collegeville; Global Any Pfizer SiteSenior$176,600 - $294,3008+ years
Apply Use Your Power for Purpose
Everything we do, every day, is driven by an unwavering commitment to the patients, healthcare providers, and customers who depend on us. In Global Commercial Strategy (GCS), we translate science of R&D into value for patients and Pfizer — from early development through launch, growth, and LOE lifecycle. GCS serves as the strategic engine and commercial voice across the asset lifecycle — shaping asset positioning and evidence generation, leading global launches, and driving sustained access and brand performance through market and payer insights, broad access, & commercial rigor. We take pride in shaping how innovative medicines reach the people who need them most, and ensuring they are accessible, understood, and valued across every market. Our success is anchored in the following Pfizer Blueprint values: Science, Technology, Transformation and Colleagues. Whether you are defining strategy, managing brands at different lifecycle, or building the capabilities that power our commercial engine, your work directly shapes patient outcomes and the long-term success of Pfizer's portfolio.
What You Will Achieve
The Director, Portfolio Strategy is an individual contributor role within the Inflammation & Immunology (I&I) Early Commercial Business, part of the Global Commercial Strategy organization, reporting to the I&I Portfolio Strategy & Disease Area Lead (“DAL”). This role is responsible for developing and supporting portfolio strategy, early commercial assessments, and investment decision support across the I&I pipeline. The colleague will bring strong strategic judgment, analytical rigor, and scientific curiosity to help shape portfolio priorities, product concepts, and differentiated commercial opportunities across autoimmune and inflammatory diseases.
The broader I&I and Rare Disease portfolio represents significant strategic value to realizing Pfizer's vision to achieve leadership via breakthroughs in prioritized diseases and biological axes, with the goal of generating highly differentiated, multi-indication mega-blockbusters. Today, the portfolio delivers more than $10B globally, with 22 ongoing clinical studies underway to significantly expand the product portfolio over the next several years. This role will contribute to that ambition by helping shape I&I portfolio strategy and early commercial decision-making across high-value pipeline and lifecycle opportunities.
The Director will partner closely with R&D, Medical Affairs, Global Access Strategy & Pricing (GASP), Business Analytics & Insights, Competitive Intelligence, Business Development, and US and International Commercial teams to translate scientific, clinical, market, access, and competitive insights into clear portfolio recommendations. This role is focused on early commercial strategy and portfolio decision-making. The Director will help advance disciplined trade-off decisions, long-range portfolio thinking, and AI-enabled ways of working that support patient impact and enterprise value realization for the I&I portfolio.
Responsibilities:
I&I Portfolio Strategy and Long-Range Planning:
Support development of long-range commercial and portfolio strategy for the I&I Early Commercial Business, spanning early pipeline assets, lifecycle opportunities, and emerging disease areas.
Synthesize scientific, clinical, commercial, access, competitive, and patient insights to inform portfolio priorities and strategic trade-offs.
Assess opportunities across near-, mid-, and long-term horizons to identify areas of differentiated value creation for Pfizer's I&I portfolio.
Translate portfolio strategy into clear recommendations, implications, and decision materials for leadership and governance discussions.
Monitor shifts in the I&I scientific and competitive landscape to identify emerging trends, risks, and potential development opportunities.
Early Commercial Assessment and Product Concept Development:
Develop and refine early commercial assessments for I&I pipeline assets, indications, mechanisms, and disease-area opportunities.
Support development of product concepts, target product profile input, positioning hypotheses, market archetypes, and commercial opportunity assessments.
Translate unmet need, standard of care, competitive dynamics, patient/HCP insights, and access considerations into differentiated commercial hypotheses.
Provide commercial input to clinical development, evidence generation, lifecycle, and indication sequencing discussions in partnership with cross-functional colleagues.
Help identify key value drivers, risks, uncertainties, and evidence needs that may influence future launch potential and portfolio value.
Business Development and External Innovation Support:
Support commercial assessments of external innovation and Business Development opportunities relevant to the I&I portfolio.
Contribute to opportunity assessments, valuation inputs, market-sizing assumptions, competitive scenarios, and strategic fit evaluations.
Partner with Business Development, R&D, BAI, GASP, and Competitive Intelligence colleagues to pressure-test assumptions and identify key decision points.
Develop clear, executive-ready materials that communicate commercial opportunity, strategic rationale, risks, and portfolio implications.
Cross-Functional Partnership and Governance:
Partner with the I&I Portfolio Strategy & DAL and cross-functional stakeholders to ensure a strong commercial voice is incorporated into early development and portfolio decisions.
Support preparation for governance forums, portfolio reviews, strategy discussions, and investment decision meetings.
Build trusted working relationships across R&D, Medical Affairs, GASP, BAI, Competitive Intelligence, Business Development, and Commercial Regions.
Influence without direct authority by aligning stakeholders around shared insights, strategic choices, and implications for the I&I portfolio.
AI-Native Ways of Working:
Use AI-enabled tools to support scientific and competitive landscape synthesis, market insight generation, scenario development, and strategy workstream efficiency.
Apply AI-augmented approaches to accelerate analysis, identify patterns across complex data sources, and improve quality and consistency of strategic outputs.
Help embed responsible, compliant AI-enabled ways of working into early commercial strategy, portfolio assessment, and decision-support processes.
Stay current on emerging tools and practices that can strengthen commercial strategy development and portfolio decision-making.
Here Is What You Need (Minimum Requirements)
Applicant must have a bachelor's degree with at least 8 years of experience; OR a master's degree with at least 7 years of experience; OR a PhD with 5+ years of experience
Experience in pharmaceutical, biotechnology, life sciences, strategy consulting, corporate strategy, commercial development, business development, forecasting, market research, analytics, or related field.
Strong strategic and analytical skills, with ability to synthesize complex scientific, clinical, market, access, and competitive information into clear recommendations.
Experience supporting portfolio strategy, early commercial assessment, business case development, opportunity assessment, or cross-functional strategic planning.
Demonstrated ability to manage multiple priorities and deliver high-quality work in a matrixed environment.
Strong communication, organization, problem-solving, and stakeholder management skills.
Bonus Points If You Have (Preferred Requirements)
Experience in Inflammation & Immunology, autoimmune disease, specialty care, or other complex therapeutic areas preferred.
Experience with early commercial strategy, commercial development, portfolio management, corporate strategy, or Business Development assessments.
Ability to quickly understand scientific and clinical data and translate implications for commercial opportunity, differentiation, and portfolio value.
Experience developing market assessments, product concepts, forecasts, business cases, investment rationales, or strategic options for senior decision-makers.
Understanding of market access dynamics, payer considerations, evidence generation, and value demonstration.
Comfort working in an AI-native or AI-augmented environment; experience using AI tools to support strategy, synthesis, or analysis is a plus.
Ability to thrive in ambiguity, make recommendations with incomplete information, and adapt to evolving portfolio priorities.
Discretion, sound judgment, and trustworthiness in handling confidential or sensitive organizational matters.
Work Location Assignment: Hybrid
Relocation assistance may be available based on business needs and/or eligibility.

Candidates must be authorized to be employed in the U.S. by any employer.
U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future.

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EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
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