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Senior Scientist, Conjugation Process Development
PfizerUnited States - Washington – BothellSenior$93,600 - $156,0009-11 years
Apply Job Description
Why Patients Need You
Pfizer’s purpose is to deliver breakthroughs that change patients’ lives. Research and Development is at the heart of fulfilling Pfizer’s purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best-in-class medicines to patients around the world.
What You Will Achieve
As a Senior Scientist, you will be at the center of our operations and you’ll find that everything we do, every day, is in line with an unwavering commitment to quality. You will be a member of our growing Conjugation Process Development team and will lead antibody-drug conjugate (ADC) process development projects ranging from early-phase clinical molecules through late-stage or commercial products. You will contribute to the development of ADC products targeting cancer to make a meaningful difference in people's lives. You will be recognized as a technical expert and a scientific contributor. With your deep knowledge of the discipline, you will be an active team member whose decisions impact the project. You will be using your scientific judgment to adapt standard methods and techniques by applying prior work experience. You will be forecasting and planning resource requirements for your project team. Your creativity in developing novel processes and new ideas will be used frequently. You will undertake mentoring activities to guide team members.
It is your innovative scientific temperament that will help in making Pfizer ready to achieve new milestones and help patients across the globe.
Role responsibilities
Independently design, execute, and interpret studies intended to answer a defined question within the defined timeframe. Design subsequent experiments upon interpretation of data.
Monitor results, identify problems, and develop solutions.
Facilitate technology/assay transfers internally/externally.
Regularly contribute at department and project team level and represent the group on multidisciplinary teams.
May present at national/international forums.
Author and review technical reports, manufacturing documents, regulatory submissions and publications.
Identify areas for process improvement and technology development and propose solutions
Qualifications
Must Have
Bachelor's Degree with 9 to11 years of experience, Master's Degree with 7 to 8 years of experience, or PhD and 0-3 years of experience
Degree in chemistry, biochemistry, chemical engineering, or related field
Direct experience with antibodies, proteins, and/or bioconjugation
Good understanding of analytical protein characterization (HPLC, IEF, CE-SDS)
Willingness to work with highly potent cytotoxic molecules
Ability to perform complex data analysis
Excellent oral and written communication skills
Foundational understanding of organic chemistry, reaction mechanisms, and process development
Nice to Have
Experience with tangential flow filtration
Experience using statistical and data analysis software, such as JMP, for experimental design, data visualization, and interpretation.
Experience with GMP manufacturing
Familiarity with CMC team function
Experience with technology transfer to manufacturing
Familiarity with chemical synthesis, protein modification, bioconjugation chemistry, and the application of analytical technologies to process development
Other Job Details
Work Location Assignment: On Premise
Relocation assistance may be available based on business needs and/or eligibility.

Candidates must be authorized to be employed in the U.S. by any employer.
U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future.

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EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
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Research and Development