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DPMS Manufacturing Execution Systems (MES) Engineer
PfizerUnited States - Connecticut - Groton$68,600 - $114,300
Apply Use Your Power for Purpose
Our breakthroughs would not make it to the hands of patients without our pharmaceutical manufacturing team. We rely on a team of dedicated and agile members who understand the importance and impact of their role in Pfizer’s mission. Patients need colleagues like you who take pride in their work and always look to improve outcomes. You will help to ensure that patients and physicians have the medicines they need when they need them. Your contributions will be vital in achieving project tasks and goals, fostering a collaborative team environment, and enabling Pfizer to reach new milestones and provide aid to patients worldwide.
What You Will Achieve
The DPMS Manufacturing Execution Systems Engineer I supports and advances key digital systems, process automation, data visibility, and data integration capabilities across Drug Product Manufacturing and Supply (DPMS). This includes support for manufacturing, materials planning, inventory management, and related DPMS processes.
This role provides critical engineering support within DPMS, helping ensure validated digital solutions, analytics, and core systems reliably enable daily operations, compliance requirements, and business growth initiatives.
Working in a structured environment, the MES Engineer applies foundational business analysis and digital skills through established procedures and documented practices. The role contributes to project tasks, system sustainment, and validated digital solutions that support compliant, reliable DPMS operations.
How You Will Achieve It
In this role, you will be responsible for:
Manufacturing Systems Support
Support key digital systems within DPMS, including software and hardware applications used for manufacturing, materials management, and data capture and reporting.
Systems include digital execution and orchestration systems (digital logbooks, Electronic Batch Records, Biosero), data capture systems (Aveva historians, networking and data flows, RFID, Snowflake) and physical automation systems.
Daily support and troubleshooting of issues related to site manufacturing systems
Ability to understand and adjust configuration settings and creation of new forms and workflows in the system.
Support data strategy initiatives related to Manufacturing systems.
Own and maintain configuration specifications and other technical documentation
Incorporate new technologies, including Artificial Intelligence (AI) into the digital, manufacturing and materials management workflows.
Support equipment integrations to Orchestrator (Biosero) in the Smartlab.
GMP Change Management & Validation Support
Support GMP change management activities for DPMS digital systems, including documentation updates, testing support, and execution of approved changes.
Assist in verification and validation tasks for software products and digital tools following established validation procedures.
Maintain required system documentation and records in accordance with quality requirements.
Assist with routine system maintenance activities, issue tracking, and coordination with IT partners, system owners, and vendors.
Digital Coordination & Engagement
Support digital deployment and adoption activities across DPMS, including preparation of user materials, coordination of training logistics, and communication support.
Serve as a supporting point of contact for DPMS digital initiatives, escalating questions and issues appropriately.
Qualifications
Must-Have
Applicant must have a Bachelor’s degree in engineering, computer science, information systems or a related field with any years of experience
Entry level to early career experience supporting digital systems, analytics, or business processes
Basic understanding of computerized systems, data reporting, and business workflows.
Strong attention to detail, documentation skills, and willingness to learn in a structured environment
Ability to execute against Standard Operating Procedures and document entries in a compliant manner
Demonstrated capability to work as a team member in a matrix development team• Strong analytical and computer skills
Excellent oral and written communication skills
Ability to maintain a safe work environment
Nice-to-Have
Experience with one or more of the following platforms is a plus: Opstrakker, OSISoft PI/Aveeva historian, MS SQL, Python, Snowflake, AI tools, Kepware
Understanding of programming, and proficiency in at least one language
Experience in a GMP manufacturing production environment
Experience with GMP Validation Lifecycles (Equipment or Software)
Experience using common AI tools, including generative technologies such as ChatGPT or Microsoft Copilot, to support problem solving and enhance productivity. Demonstrated curiosity for exploring how these tools can improve outcomes and understanding of responsible AI practices, including risk management and ethical use
Work Location Assignment: On Premise
Relocation assistance may be available based on business needs and/or eligibility.

Candidates must be authorized to be employed in the U.S. by any employer.
U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future.

Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
Pfizer endeavors to make www.pfizer.com/careers accessible to all users. If you would like to contact us regarding the accessibility of our website or need assistance completing the application process and/or interviewing, please email disabilityrecruitment@pfizer.com. This is to be used solely for accommodation requests with respect to the accessibility of our website, online application process and/or interviewing. Requests for any other reason will not be returned.
To learn more about acceptable and prohibited uses of AI during the recruitment process, please review our candidate AI-use guidelines available on Pfizer Careers.

Manufacturing