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Position Summary
You will join a DMPK drug discovery team in Spain to influence how we translate science into safer, more effective medicines. You will design and deliver modelling and simulation strategies to support discovery and early development projects. You will work closely with project teams across disciplines and locations to inform dose decisions, drug-drug interaction risk, and human pharmacokinetics. We value collaborative thinkers who communicate clearly, mentor others, and apply modelling with scientific rigour and practical judgement. This role is part of GSK’s Global Health Medicines R&D team which aims to positively impact infectious diseases such as Malaria, Tuberculosis, and AMR that disproportionally impact lower income countries.
Responsibilities
This role will provide YOU the opportunity to lead key activities to progress YOUR career. These responsibilities include some of the following:
Lead development and application of pharmacokinetic and pharmacokinetic-pharmacodynamic (PK/PD) models for small molecules and other modalities to inform project decisions.
Design and deliver translational modelling strategies, including dose prediction and human exposure projections.
Assess and quantify drug-drug interaction (DDI) risk using in vitro-in vivo translation and modelling approaches.
Communicate model assumptions, results and uncertainty clearly to cross-functional teams and governance bodies.
Mentor and coach colleagues on modelling methods, good practices and scientific interpretation.
Contribute to regulatory and internal documents with clear, evidence-based modelling narratives.
Qualifications/Skills
Basic Qualifications:
Degree in Pharmacology, Pharmaceutics, Pharmacokinetics, Mathematics, Bioengineering, or a related discipline.
Practical experience in population PK, PBPK, or mechanistic PK/PD modelling in a biopharma setting.
Hands-on experience with modelling software such as, Matlab (symbiology), Monolix, Simcyp, GastroPlus, or equivalent.
Experience translating in vitro and preclinical data to humans.
Strong written and verbal communication skills in English; ability to explain modelling outcomes to non-specialists.
Experience working in cross-functional project teams.
Preferred Qualifications:
If you have the following characteristics, it would be a plus:
PhD in a relevant field or equivalent industry experience.
Experience with drug-drug interaction modelling and enzyme/transporter mechanistic frameworks.
Familiarity with multiple modalities beyond small molecules.
Experience preparing modelling sections for regulatory documents and interacting with regulators.
Programming skills in R, MATLAB, or Python for data analysis and model development.
Experience in infectious disease drug discovery.
Track record of mentoring and developing junior scientists.
Work Location:
This role is based in the Tres Cantos, Spain and offers a hybrid working model, combining on-site and remote work.
Why GSK?
Uniting science, technology and talent to get ahead of disease together.
GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases – to impact health at scale.
People and patients around the world count on the medicines and vaccines we make, so we’re committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.
Should you require any reasonable adjustments or arrangements to support you during the recruitment process, specific to your individual needs, please contact us on esp-inclusion.recruitment@gsk.com.
Please note should your enquiry not relate to adjustments, we will not be able to support you through these channels.
GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.
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