Research Associate, Molecular Biology

An affiliate of Colossal is seeking a motivated and detail-oriented Research Associate to join our interdisciplinary team at the intersection of molecular and developmental biology. This role offers the opportunity to work closely with scientists developing cutting-edge approaches to drive novel applications in the modification of phenotypes in avians. The successful candidate will support ongoing research projects by performing a range of cellular and tissue-based assays, including in situ hybridization, flow cytometry, histology, and immunofluorescence staining. 

This role is based in Dallas, TX. Relocation assistance is available.

Duties and Responsibilities

• Collaborate with developmental biologists to analyze gene expression and function across different developmental stages.
• Perform in situ hybridization (ISH) to localize and quantify RNA/DNA targets in tissue and whole embryo samples
• Prepare and process tissue samples for histology, including sectioning, fixation, and staining (H&E and special stains)
• Perform immunofluorescence (IF) staining and support imaging/microscopy workflows
• Conduct flow cytometry experiments, including sample preparation, staining panel setup, data acquisition, and basic analysis
• Screen constructs in developing avian embryos to quantify expression patterns.
• Produce transfection reagents to aid experimental workflows.
• Analyze and interpret experimental data, providing recommendations to guide project direction.
• Participate in meetings, generate reports, and present findings to ensure alignment with project milestones.
• Maintain accurate, detailed laboratory records and demonstrate strong organizational skills.

Required Skills and Qualifications

• Bachelor’s degree (B.S./B.A.) in molecular biology, or a related life science field with 1 or more years of hands-on research experience in industry or academic research labs.
• Hands-on experience in molecular cloning, plasmid construction, and plasmid preparation (mini-, midi-, and maxi-prep).
• Demonstrated hands-on experience with at least two of the following: microscopy (confocal and/or lightsheet), in situ hybridization, flow cytometry, histology, immunofluorescence staining, (experience with all four strongly preferred)
• Skilled in PCR primer design and PCR optimization/troubleshooting.
• Strong organizational skills with the ability to manage multiple projects simultaneously and meet deadlines.
• Excellent written and oral communication skills, with demonstrated problem-solving abilities.

Preferred Skills and Abilities

• Experience handling vertebrate embryos.
• Familiarity with microscopy/imaging software (e.g., Imaris, ImageJ or similar)
• Experience with transfection reagents (i.e. lipofectamine or electroporation)
• Familiarity with high-throughput automation platforms for molecular biology workflows.