Senior Director, Head of Marketing

Position Summary

You are a seasoned rare disease commercialization leader who thrives at the intersection of science, strategy, and execution. You have led — or been a critical architect of — at least one rare disease launch, and you understand that in a small-patient, high-science category, every HCP interaction and every patient touchpoint matters. You know how to build a brand from the ground up, how to mobilize a field team around a clear and compelling narrative, and how to make the most of a narrow but deep opportunity.

The Senior Director, Head of Marketing will serve as the commercial brand authority for Calci (encaleret) — BridgeBio's oral CaSR negative allosteric modulator in NDA review for Autosomal Dominant Hypocalcemia Type 1 (ADH1). This is a first-in-class asset targeting a chronically underserved rare endocrine population, and this role represents a defining commercial leadership opportunity. You will own the full marketing function for Calci: leading HCP marketing, patient marketing, and KOL engagement under a single integrated brand strategy. You will report directly to the SVP, Sales & Marketing — Endocrinology and will be expected to be on-site in both our San Francisco and Palo Alto home offices on a weekly basis.

This is not a role for someone who needs a playbook. It's a role for someone who writes one.

What You'll Do

Brand Strategy & Launch Leadership

• Own the Calci brand strategy end-to-end — positioning, messaging architecture, segmentation, and go-to-market sequencing — ensuring full alignment from pre-NDA approval through Year 1+ commercialization
• Lead all brand planning milestones, including annual brand plan, launch readiness assessments, and BOD-level commercial reporting
• Serve as the senior commercial voice on the Calci Product Team, embedding market realities into cross-functional planning across Medical Affairs, Regulatory, Market Access, and Patient Advocacy
• Build and maintain a dynamic competitive intelligence function, monitoring the ADH1 and broader hypoparathyroidism landscape and translating findings into strategic decisions
• Partner with Value & Access to shape the payer value proposition and ensure access strategies are integrated into brand planning from day one

People Leadership & Team Development

• Directly lead and develop a team of 4, including: Director, HCP Marketing; Director, Patient Marketing; and two KOL Engagement Leads — setting individual performance goals, coaching toward professional growth, and building a cohesive, high-performing marketing organization
• Foster a culture of intellectual rigor, creative ambition, and patient-first accountability across the marketing team
• Act as the connector between team workstreams, ensuring HCP, patient, and KOL strategies are mutually reinforcing and aligned under one brand narrative
• Develop the next generation of commercial talent within the team through active mentorship, stretch assignments, and transparent performance management

HCP Marketing

• Oversee the development of a field-ready HCP promotional platform — including clinical messaging, EAM enablement tools, and channel strategy — built on deep insight into endocrinologist and nephrologist decision-making
• Ensure EAM (Endocrine Account Manager) engagement materials reflect the Calci scientific story with precision, clarity, and promotional compliance
• Lead commercial advisory boards and insight-generation programs to continuously refine HCP strategy and ensure message resonance
• Partner with Market Insights to develop HCP segmentation and targeting frameworks, including tiered engagement models for high-value prescribers

Patient Marketing & Disease Awareness

• Guide the patient marketing director in developing a robust DTC and patient-facing strategy, with a focus on diagnosis acceleration, disease education, and treatment adherence for ADH1 patients
• Oversee the commercial patient support ecosystem in partnership with specialty pharmacy and patient services, ensuring a seamless patient journey from identification through persistency
• Champion familial cascade testing as a patient identification lever, ensuring that commercial programs support structured proband communication and relative testing uptake

KOL Engagement

• Provide strategic direction to two KOL Engagement Leads, ensuring a coordinated, insight-driven KOL plan that spans identification, profiling, advisory board engagement, and speaker bureau development
• Oversee commercial KOL congress strategy and ensure BridgeBio's Calci commercial presence at key endocrine and rare disease meetings is impactful and insight-generating
• Guide the development and governance of the commercial speaker bureau program in alignment with compliance and legal requirements

Forecasting, Analytics & Business Reporting

• Work with Market Insights to build and pressure-test launch forecasting models and establish measurable KPIs across all marketing programs
• Develop and present commercial updates to senior leadership and the Board of Directors, synthesizing brand performance, market dynamics, and strategic pivots
• Establish a metrics-driven culture within the marketing team, driving accountability against leading and lagging brand indicators

No Matter Your Role at BridgeBio, Successful Team Members Are:

• Patient Champions, who put patients first and uphold strict ethical standards
• Entrepreneurial Operators, who drive toward practical solutions and have an ownership mindset
• Truth Seekers, who are detailed, rational, and humble problem solvers
• Individuals Who Inspire Excellence in themselves and those around them
• High-quality executors, who execute against goals and milestones with quality, precision, and speed

Where You'll Work 

This is a San Francisco/Bay Area based role; joining office-based collaboration Tuesday through Thursday weekly, is required

Who You Are

• 12+ years of commercial biotech or pharmaceutical experience, with at least 7 years in pharmaceutical/biotech marketing
• Prior people management experience required; experience building or scaling a marketing team in a launch setting strongly preferred
• Rare disease launch experience required — endocrinology or nephrology experience is a significant differentiator
• Demonstrated success owning brand strategy through launch, including brand planning, promotional development, and commercial execution
• Proven track record leading KOL engagement programs and commercial advisory board design
• Experience developing and managing both HCP and patient marketing strategies simultaneously
• Comfort operating in a pre-launch, high-ambiguity environment — able to set direction and drive execution before full commercial infrastructure is in place
• Strong working knowledge of FDA promotional guidelines, fair balance, and rare disease compliance requirements
• Exceptional oral, written, and executive presentation skills — including comfort with BOD-level deliverables
• Ability to travel (~25%) for key congresses, advisory boards, and field engagement
• Bachelor's degree required; MBA or advanced science degree preferred

Key Attributes

• Deeply passionate about improving the lives of patients with rare, genetic, and underdiagnosed diseases
• Visionary brand thinker with the tactical acumen to translate strategy into field-ready execution
• Natural leader and talent developer — someone who builds loyalty through clarity, candor, and commitment to team success
• Collaborative by default, with the spine to advocate for bold commercial decisions when the data and science support it
• High EQ and self-awareness; understands the importance of managing up, across, and down with equal skill
• True entrepreneurial spirit — BridgeBio was built to do things differently and address the needs of underserved populations, driven by science and unrelenting passion for patients

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