Scientist

Position Information:

Provide support services to satisfy the overall operational objectives of the National Institute on Aging. The primary objective is to provide services and deliverables through performance of support services.

Additional Qualifications:

Certifications & Licenses

• Master’s degree in Biology or a related discipline.

Field of Study

• Biology

Software

• MS office suite

• PowerPoint

• NIH POTS

• Outlook

Skills

• Strong communications skills, both oral and written.

Deliverables:

• Work products and documents related to implement and performing studies that are aimed at detecting age-associated changes in Protein Quality Control; perform longitudinal and cross-sectional design experiments. - Ad-Hoc

• Work products and documents related to protein chemistry, assessment of protein posttranslational modifications, protein-ligand binding, protein-protein interactions, protein extraction/quantitation from cell and tissue lysates, with a strong technical background in immunolabeling. - Ad-Hoc

• Work products and documents related to implementing protein assays and immunolabeling assays; conduct specific, technical enzymatic and protein analyses, and data reduction; perform and analyzed implemented assays. - Ad-Hoc

• Work products and documents related to collecting, analyzing and interpreting data; update and maintain laboratory notebooks and databases; prepare summaries and reports based on results and findings. - Ad-Hoc

• Work products and documents related to writing scientific manuscripts; submit drafts for editing and approval; develop and deliver presentations; attend laboratory meetings; present results and findings for staff discussion. - Ad-Hoc

• Clean Equipment - Ad-Hoc

• Meet with lab members to present updates - Weekly

Statement of Work Details:

• Implement and perform studies that are aimed at detecting age-associated changes in Protein Quality. - 1
• Perform longitudinal and cross-sectional design experiments that span an estimated four-year period involving aging mice, via a multiomics approach as determined by the laboratory. - 2
• Participate in the writing of scientific manuscripts generated using data collected from the studies and analyzes conducted; submit drafts for editing and approval. - 3
• Implement and perform studies that are aimed at detecting age-associated changes in Protein Quality. - 4
• Perform longitudinal and cross-sectional design experiments that span an estimated four-year period involving aging mice, via a multi-omics approach as determined by the laboratory. - 5

• Supports the planning and execution of research experiments in the context of the laboratory's overall research program.

• Evaluate new techniques, instruments, and software for potential incorporation into current SOP.

• Advance the science in the laboratory through new procedures and discoveries.

• Advance the science through proposing and investigating new target projects for initiation based on novelty and relevance to human health.

• Supports laboratory staff on research projects and techniques.

• Work with staff on the interpretation of experiments performed by research scientists.

• Independently direct and conduct special research projects that have a high priority for the laboratory with special emphasis in the development of novel research treatments.

• Work with postdoc/biological scientists to perform statistical analysis for research projects.

• Work with staff on assay design and method development using an array or experimentation.

• Review scientific data to determine if a research program can be developed around an idea or data package.

• Work with staff on protein chemistry, assessment of protein post-translational modifications, protein-ligand binding, protein-protein interactions.

• Collaborate with staff on protein extraction/quantitation from cell and tissue lysates, with a strong technical background in immunolabeling (western blotting, immunofluorescence/immunohistochemistry, and immunoprecipitation).

• Implementing protein assays and immunolabeling assays.

• Maintains laboratory equipment and the training of others in their use.

• Calibrate, maintain and troubleshoot instruments and equipment in the laboratory.

• Maintain and perform staff training on scientific instrumentation, including HPLCs, microanalytical balances, centrifuges, spectrophotometers, vacuum apparatus and analytical equipment.

• Operate, troubleshoot and train others to use laboratory equipment and software.

• Provide advice and assistance to users in designing experiments, using instrumentation, data acquisition and analysis, and preparing figures for publication.

• Assists in maintaining adequate space and facilities for ongoing and projected research studies.

• Manage scientific equipment and resources (e.g. reagents, stocks of frozen sells, animal samples) including acquisition, documentation and storage.

• Participate in the laboratory’s review of future proposals for resource allocations. Evaluates, analyzes and interprets research data, communicates results and methods in reports, presentations, and manuscripts.

• Write technical reports and prepare manuscripts.

• Oversee project data quality; analyze and interpret project data.

• Conduct bioinformatics data analyses and statistical analyses; prepare data for abstracts and manuscripts.

• Maintain a detailed and up-to-date electronic laboratory notebook detailing all experiments.

• Conduct specific, technical enzymatic and protein analyses, and data reduction.

• Perform and analyzed implemented assays.

• Collect, analyze and interpret data; update and maintain laboratory notebooks and databases.

• Coordinates with junior staff to modify research protocols.

• Work with staff to confirm assay results and evaluate new techniques and instruments; search literature; propose, design and test alternative assays for difficult screening targets; confirm assay results; develop secondary assays.

• Work with Principal Investigators in scheduling and prioritizing instrument usage.

• Coordinate projects being developed in the laboratory, proposing SAR strategies and monitoring their progress.

• Coordinate with IT staff on all software issues specific to the chemistry group and on all computer problems.

• Identify and advise IC leadership on opportunities and program areas, research gaps and relevant program needs; make recommendations for consideration.

• Participate in establishing criteria and standards for others to follow in the planning, review and evaluation of bioinformatics research projects.

• Suggest alternative or complementary approaches to experiments.

• Presents research at national scientific meetings and symposia.

• Prepare oral presentations and posters for internal and external groups/conferences.

• Co-author manuscripts on research projects; publish in peer-reviewed journals.

• Write papers and abstracts detailing research efforts and results for publication in peer-reviewed journals; prepare PowerPoint presentations as appropriate.

• Give posters and presentations detailing work at regional and national scientific meetings.

• Review, edit, and, as needed, write first drafts of papers, posters and manuscripts.

• Give posters and presentations detailing work at regional and national scientific meetings.

• Present results of clinical and experimental research at recognized scientific meetings by lectures and exhibits (poster sessions).

• Develop and deliver presentations using data collected from the studies and analyses conducted.

• Attend laboratory meetings; present results and findings for staff discussion.

• Provides interpretation of results, guidance, and scientific support to the management team.

• Search existing literature for new and/or relevant techniques.

• Assist the lab staff in the creation and preparation of a variety of documents required by the lab’s scientific activities.

• Produce research reports and regularly communicate results to staff and collaborators.

• Prepare information for and attend advisory, review committee and panel meetings; respond to issues and concerns about specific applications/proposal pertaining to assigned program area.

• Prepare summaries and reports based on results and findings.

• Mentors junior level scientists.

• Train staff on the proper usage of equipment.

• Train staff in a wide variety of techniques used in the laboratory.

• Train staff in the proper breeding/genotyping techniques used to maintain various knock out, knock in, and transgenic lines used by the laboratory members.

• Provide scientific and technical expertise to all visiting fellows, post-docs, and technicians.

• Work with staff on protein chemistry, assessment of protein post-translational modifications, protein-ligand binding, protein-protein interactions.

• Collaborate with staff on protein extraction/quantitation from cell and tissue lysates, with a strong technical background in immunolabeling (western blotting, immunofluorescence/immunohistochemistry, and immunoprecipitation).

• Implementing protein assays and immunolabeling assays.

• Conduct specific, technical enzymatic and protein analyses, and data reduction.

• Perform and analyzed implemented assays.

• Collect, analyze and interpret data; update and maintain laboratory notebooks and databases.

• Prepare summaries and reports based on results and findings.

• Participate in the writing of scientific manuscripts generated using data collected from the studies and analyzes conducted; submit drafts for editing and approval.

• Develop and deliver presentations using data collected from the studies and analyses conducted.

• Attend laboratory meetings; present results and findings for staff discussion.